BME Webmaster
© 2002-2006
Daphne Weihs, Ph.D.
Senior Lecturer

E-mail: daphnew@tx.technion.ac.il
Homepage: www.bm.technion.ac.il/~daphnew
Office phone: 04-8294134
Office Room: 258

 

B. Sc. 1998 Department of Chemical Engineering, Technion

M. Sc. 2000 Department of Chemical Engineering, Technion

Ph. D. 2004 Department of Chemical Engineering, Technion

Post-doc 2006 University of California at Los Angeles

 

Office: room 258, Tel. 4134

Lab:    room 256, Tel. 3118
Field of research:
Bio-rheology and Bio-microrheology. Rheological and mechanical properties of living cells with regard to disease and health.
Research interests:

- Structure and mechanics of live cells

- Disease development and its influence on structure, function, and viability of cells

- Diagnosis of cellular health through mechanical microrheological properties

- Cell adhesion and spreading on bio-surfaces as a function of external conditions and pre-stress

- Sedimentation and transport of suspension cells and measurements within

 

Main approaches:

- Real-time, high-resolution fluorescence microscopy with combined time-lapse

- Particle tracking microrheology

- Various cell biology techniques (immunofluorescence, viability and proliferation, etc.)

- Laser tweeezers for accurate force application and measurement in and on cells

- Image processing for high-resolution particle tracking

Selected publications:

1.          Fred M. Konikoff, Dganit Danino, Daphne Weihs, Moshe Rubin, and Yeshayahu Talmon, "Microstructural Evolution of Lipid Aggregates in Nucleating Model and Human Biles Visualized by Cryogenic Transmission Electron Microscopy", Hepatology 31, 261-268 (2000). (Featured in: The New York Times, The Jerusalem Post, Haaretz Tel Aviv)

2.          Dganit Danino, Daphne Weihs, Raoul Zana, Greger Oradd, Goran
Lindblom, Masahiko Abe, and Yeshayahu Talmon, “Microstructures in the Aqueous Solutions of a Hybrid Anionic Fluorocarbon/Hydrocarbon Surfactant”, J. Colloid Int. Sci. 259, 382-390 (2003).

3.          Daphne Weihs, Dganit Danino, Aurora Pinazo-Gassol, L. Perez, Elias I. Frances, and Yeshayahu Talmon, “Self-Aggregation in Dimeric Arginine-Based Cationic Surfactants Solutions”, Colloids and Surfaces A 255, 73-78 (2005).

4.          Daphne Weihs, Judith Schmidt, Ilana Goldiner, Dganit Danino, Moshe Rubin, Yeshayahu Talmon, and Fred M. Konikoff, “Biliary Cholesterol Crystallization Characterized by Single Crystal Cryogenic-Electron Diffraction”, Journal of Lipid Research 46, 942-948 (2005).

5.          Daphne Weihs, Thomas G. Mason, and Michael A. Teitell, “Bio-microrheology: A Frontier in Microrheology”, Biophysical Journal 91, 4296-4305 (2006).

6.          Daphne Weihs, Michael A. Teitell, and Thomas G. Mason, “Simulations of Complex Particle Transport in Heterogeneous Active Liquids”, Microfluidics and Nanofluidics 3, 227-237 (2007).

7.          Daphne Weihs, Judith Schmidt, Dganit Danino, Ilana Goldiner, Diana Leikin-Gobbi, Arie Eitan, Moshe Rubin, Yeshayahu Talmon, and Fred M. Konikoff, “A Comparative Study of Microstructure Development in Paired Hepatic and Gallbladder Biles”, Biochimica Biophysica Acta 1771, 1289–1298 (2007).

8.          Daphne Weihs, Thomas G. Mason, and Michael A. Teitell, “Transport, rheology, and internal structure of live cells: Effects of cytoskeletal disruption”, Physics of Fluids 19, 103102 (2007). (Featured in: the Virtual Journal of Nanoscale Science & Technology -- October 22, 2007)

 
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